In the public equity market, investor behavior of late has been a bit
mystifying to some, and led others to suggest that Wall Street is wide
open for high-risk investments this season. The initial public offerings
completed in the health care industry during September include an
unprofitable e-health company that raised just shy of $135 million, a
company that does not yet operate a business and a company developing
human embryonic stem cell-based therapies (and as if that’s not
controversial enough, the same company is joint venturing with a big
pharma that’s in a little trouble). Health care companies completed four
IPOs and eight secondary offerings during the month of September, and
filed for four new IPOs and five secondaries; two withdrew IPOs.
With social disparity and terror constantly in the news, maybe it’s not
surprising that investors are turned on by the idea of a national
community focused on interacting to improve health, wellness and the
delivery of care, even if that community is in cyberspace. So are the warm
fuzzies what’s driving investors to buy up shares of WebMD Health
(NASDAQ: WBMD)? Because it is not the profitability—WebMD is actually not
sure when, or if, it will become profitable, except to say that it
was for one year, 2004.
WebMD is now separate from
its parent, Emdeon Corporation (NASDAQ: HLTH), which will continue
to control the company. Emdeon will own all of WebMD’s outstanding Class B
common stock, representing approximately 87.5% of WebMD’s outstanding
common stock and approximately 97.1% of the combined voting power of the
outstanding common stock. Incidentally, M.D. On-Line, Inc., a
provider of electronic claims solutions to better connect health care
payers and providers with offices in New Jersey and California, received
an unfavorable court ruling in its effort to prevent WebMD’s parent from
changing its name to Emdeon.
One investment banker was quoted as saying it was "trading
forces, not fundamentals" in the first few hours of the public offering of
Class A common stock that drove WBMD’s share price up from the $17.50 per
share IPO price to as high as $30 per share. According to some investors,
the underwriters sold small parcels of several hundred shares each, so
multiple small trades would have to be made by anyone wanting to build a
larger position in the company. An unassociated journalist suggested the
offering is only intended to make the "big fishies" rich. (Smart fish.) It
will be interesting to see how long major investors will hold onto the
hook waiting for this company to become profitable, and how smaller
investors will react when analysts begin issuing research. As of this
publication, WebMD’s stock had settled down to $24 per share.
Among the other companies that didn’t make such a splash
but still braved the float, Genomic Health, Inc. (NASDAQ: GHDX) got
its initial public offering of 5,016,722 shares priced at $12.00 per
share. J.P. Morgan Securities Inc. and Lehman Brothers Inc.
acted as joint book-running managers for the offering, with Piper
Jaffray & Co., Thomas Weisel Partners LLC and JMP Securities
LLC acting as co-managers.
Avalon Pharmaceuticals, Inc. (NASDAQ: AVRX) announced
the pricing of its initial public offering of 2,750,000 shares of common
stock at $10.50 per share. W.R. Hambrecht + Co., through its own
auction-based IPO process, led the offering, with Legg Mason Wood
Walker Incorporated and Susquehanna Financial Group LLP serving
as co-managers. Avalon, a biopharma headquartered in Germantown, Maryland,
is focused on the discovery and development of small-molecule therapeutics
for the treatment of cancer.
BioDelivery Sciences International (NASDAQ: BDSI), a
four-year-old specialty biopharma developing technologies, including
nanotechnologies, for drug delivery, raised approximately $8.8 million in
a secondary offering of common stock. After the offering was priced, at
$2.00 per share, BDSI’s shares were trading down a bit; a year ago, they
were at about $4.00 per share. One of BDSI’s technologies would provide
oral delivery of injectables, and enhance the efficacy and reduce the
toxicity of certain oral drugs. The company has offices in North Carolina
and research facilities in New Jersey.
One of a handful of SPACs recently formed for the purpose
of acquiring a health care business, Ithaka Acquisition Corp. (OTCBB:
ITHKU) completed its IPO, raising more than $53 million; $47 million of
the proceeds is currently held in trust. Now Ithaka is looking for a
target that is valued at anywhere from $40 million to $500 million.
Ithaka was formed by the CEO of Potomoc Pharma, Inc.,
a specialty pharma; a managing director of ATP Management Group, a
venture capital firm; and Paul Brooke, a venture partner of MPM Capital—the
Boston, Massachusetts-based firm with an extensive portfolio of
biotechnology and medical technology investments. The firm has over $2.1
billion currently under management. MPM Capital has participated in the
venture financings of at least 13 companies this year alone, including
Affymax, Inc. and Verus Pharmaceuticals, and its portfolio also
includes CoTherix, Inc. (NASDAQ: CTRX) and Critical
Therapeutics, Inc. (NASDAQ: CRTX). Perhaps hinting that the target
could be a company based outside the United States, Mr. Brooke stated in a
recent press release that "high-quality, non-U.S. private mid-market
companies are seeking access to U.S. capital markets," and that spinoffs,
divestitures and partnering deals, and the absence of a robust IPO window,
are forces contributing to abundant opportunities in the health care
sectors today.
Ithaka sold 8,849,100 units, including the over-allotment
option, at a price of $6.00 per unit. The lead underwriter in the offering
was EarlyBirdCapital, Inc. EarlyBirdCapital, based in New York
City, is also expected to act as the lead underwriter in the anticipated
IPO of KBL Healthcare Acquisition Corp. and Paramount
Acquisition. Also in the works is an IPO from Oracle Healthcare
Acquisition, being underwritten by CRT Capital Group LLC, which
is headquartered in Stamford, Connecticut.
Big pharma is showing support for the development of
treatments based on human embryonic stem cells (hESC therapies). Merck
& Co., Inc. (NYSE: MRK) created a strategic arrangement with Geron
Corporation (NASDAQ: GERN), which included the purchase of common
shares in conjunction with a public offering of shares by Geron. Perhaps
Geron is hoping that whatever credibility Merck still has, as the Vioxx
trials continue, could boost public confidence in and acceptance of hESC
therapies. Merck exercised its warrant to purchase 2,000,000 shares of
Geron’s common stock with a total value of $18 million; concurrently,
Geron Corporation sold to the public 6,900,000 shares, including the
over-allotment option, for gross proceeds of $62.1 million. The
underwriters included UBS Investment Bank acting as the sole
book-running manager, with SG Cowen, Needham & Company, LLC
and Lazard Capital Markets acting as co-managers.
Pursuant to a collaboration and license agreement, Geron
and Merck will develop a cancer vaccine targeting telomerase using Merck’s
vaccine platform. Geron believes it is in a dominant patent position in
the field of telomerase, an enzyme found expressed in at least 30 types of
cancer, but not in normal cells. Though the enzyme is not purported to be
the cause of cancer, it is said to enable the indefinite reproductive
capacity of the cancer cells.
Geron also has under development cell-based therapeutics
for several diseases based on differentiated cells derived from six
different types of human embryonic stem cells—currently in testing in
animal models—including neural cells for spinal cord injury, osteoblasts
for osteoporosis, islet cells for diabetes and other types.
One company we are not likely to see a secondary from
anytime soon, if ever, is IntraBiotics Pharmaceuticals, Inc. (OTCBB:
IBPI), which received a letter from the staff of the NASDAQ stock
exchange, asserting that IntraBiotics is a public shell and therefore
subject to delisting. Earlier this year, California-based IntraBiotics
announced it had stopped trials of its drug for ventilator- associated
pneumonia (VAP), because the patients in the trial who were on the drug
suffered a higher incidence of VAP and death rates than those on the
placebo. Since then, IntraBiotics has not reported any new clinical data.