November
2006 issue
Out Of The Waiting Room, Please - Funding To Reduce Costs, Improve Care
Through Outpatient Facilities
Clinical centers established to specifically concentrate on addressing a
single disorder or therapeutic area are attracting the attention of
investors.
...
Corporate Incubation Leads To Spin-Out - Equity Round Supports Clinically
Established Delivery Technology
Although five health care companies priced IPOs during October, only one saw
its stock value increase significantly in after-market performance.
...
Mergers & Acquisitions
Health care mergers and acquisitions continued at a steady pace, and more
deals than usual came with prices during the month of October.
...
Venture Capital Market
The companies that raised larger rounds this month include a medical
malpractice insurer and a medical waste management company.
...
Private Equity Market
Biopharmaceutical companies raised some of the larger private equity
financings announced during October, and one pharma collected a milestone
payment as well as a funding round.
...
Notes & Briefs
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Healthcare Corporate Finance
News Read the past
headlines.
Companies Mentioned in this issue:
November 2006
3i Group p7, p8
3M Company p5
5AM Ventures p8
A
AAIPharma p8
Abingworth Management p7
Abingworth Mgmt. p8
ABIOMED p3
ABN AMRO Capital Life Sciences p7
ABN AMRO Life Sciences p8
Accentia Biopharmaceuticals p10
Acchillion Pharmaceuticals p6
Achaogen p8
Acorda Therapeutics p10
Action Pharma p8
ActivBiotics p3
Advent Ventures p8
AGI Dermatics p8
Allied Waste Industries p8
Alsius p5
Alternative Behavioral Services p6
Alvarado Hospital Medical p5
ALZA Corporation p1
Amedisys p3
American Access Care p4
Amsterdam Molecular Therap. p8
Amyris Biotechnologies p8
AngioDynamics p5
AnorMED p5
Apjohn Ventures p8
Aradigm p3
Aravis Venture p7
Arcturus Capital p8
Arrowhead Research p8
Asthmatx p3
AstraZeneca p12
Atrium Biotechnol. p3
Avantis Medical Systems p8
Avista Capital Partners p8
AXA Private Equity p7
Axia Health Management p5
B
Beckman Coulter p5
Berna Products p5
BFI Medical Waste p8
BIOAM/Bioamgestion p7
Bioenvision p3
Biofisica p8
Biomira p5
Biotrace International p5
BioVex Gr p3
Boehringer Ingelheim p5
Borealis Infrastructure p5
Boston Scientific p8
Bristal p5
Brontes Technologies p5
Browning Ferris Industries p8
Burrill & Company p7
BZ Bank p7
C
Cadence Pharmaceu. p3
Caisse de Depot et Placement du Quebec p7
California Clinical Trials p5
Cambrex p5
CambridgeSoft p8, p9
Canaan Partners p7
Caremark Rx p6
Carrick Institute p12
Catalyst Pharmaceut. p3
CB Health Ventures p7
CDC Entreprises Innovation p7
Cell Therapeutics p3
Center for Neuroprosthetics and BioMEMS p12
Center for Untethered Healthcare p12
Centers for Disease Control and Prevention p4
Charles River Labor. p5
Chart Venture Partners p8
Chartwell Seniors Hsg. p5
Chattem p5
CHL Medical Partners p9
Chronicity p1
Chrysalis Ventures p1
CIBC p3
Citigroup p3
Clarient p8
CNF Investments p8
CNS p5
CoDa Therapeutics p8
Cogene Biotech Ventures p7
Connetics p5
Cowen & Co. p3
Craig-Hallum Capital p3
Credit Agricole Private Equity p7
Credit Suisse p3
Crucell p5
CVS p6
Cypress Group p9
Cytheris p7
Cytyc p5
D
Danaher p5
Dawson James p3
Derma Sciences p3
DFJ Mercury p8
Diffusion Pharmaceuticals p8
DoctorsDirect.com p8
Domain Associates p8
Domain Venture Partners p8
Drug Royalty Corp. p5
Dynavax Technolog. p3
E
EarlySense p8
Edison Venture p8
Efficas p8
eHealth, Inc. p3
Eli Lilly and Company p4
Emergent BioSolut. p3
Emeritus Assisted Lvg. p5
Endo Pharmaceuticals p5
EnVivo Pharmaceuticals p8
Erasmus Louisiana Growth Fund p7
Esperance Pharmaceuticals p8
Etgar Challenge Fund p8
Exelixis p3
F
Fibromyalgia and Fatigue Centers p2
Fidelity Biosciences p8
Finistere Partners p8
First Albany p3
Flagship Ventures p7
Fleming Family & Partners p8
Forbes Medi-Tech p5
Forward Ventures p7
FoxHollow Technol. p3
Fresenius Medical p5
Friendship Village Center p5
G
GE Healthcare Financial Services p8
Genaco Biomedical p5
Gentium p3
Genzyme p5
Geron p3
GetWellNetwork p8
Gilead Sciences p5
GlaxoSmithKline p5
Global Life Science Ventures p8
Grand Angels p8
Great Point Partners p10
Grosvenor Funds p8
Growth Foundation p8
H
Hansen Medical p3
Harborside Healthcare p5
HBM BioCapital p8
HBM BioVentures p8
HBM Partners p1, p7
Health Care Ppty. Inv. p3
Healthcare Brands International p7
Healthcare Svcs. Grp. p3
HealthCare Ventures p7
HealthSpring p3
Healthways p5
Helica Instruments p5
HemoSense p3
Highland Capital Partners p8
Hippo Ventures p8
HLM Venture Partners p8
Hollywood Medical Ctr. p5
Horizon Bay Management p5
HSBC p3
Hunt BioVentures p7
I
Icos p5
Imperial Innovations p8
InforSense Limited p8
InfuSystem p5
InnovationsKapital p8
Innovative Biosensors p8
Insception Biosciences p8
Insert Therapeutics p8
IntegriChain p8
Intelligent Medical Implants p8
Investor Growth Capital p7
Ithaka Acquisition p5
Ivivi Technologies p3
J
JMP Securities p6
Johnson & Johnson p1
JPMorgan p3
K
Keller Group p5
Khosla Ventures p8
Kleiner Perkins Caufield & Byers p8
L
LAB International p5
Lazard Capital p10
LeMaitre Vascular p3
Lexicon Genetics p10
LM Partners p10
Logical Images p8
Lombard Odier Darier Hentsch p7
Long River Ventures p8
Lonza Group p5
Louisiana Fund I p8
LSP BioVentures p8
Lumenis Limited p10
Lumigen p5
M
Macroflux Corporation, p1
Marcus & Millichap p5
Maxim Group p3
McNeil Pediatrics p4
MDS Capital p7
MedCath p3
MEDecision p3
Medicus Insurance Holdings p7
MedImmune Ventures p7
MedPointe p9
MedServe p8
MedVentive p8
Memory Pharmaceuticals p10
Merck & Co. p5
Merrill Lynch p3
Merriman Curhan Ford p10
MMV Financial p8
Montreux Equity Partners p8
Morgan Stanley p3
Morgenthaler Ventures p7
Morphotek p7
MPM Capital p10
mtm laboratories p8
MultiCell Technol. p3
Murphree Venture Partners p7
MVM Limited p7
Myogen p5
N
Nabi Pharma. p5
Nanogen p5
NAPC p5
National Association of Medical Sales Representati p12
National Dentex p5
Natus Medical p5
NContact Surgical p8
New Enterprise Partners p1
Newbridge Secs. p3
NGN Capital p8
NightHawk Radiology p3
NJTC Venture Fund p8
NLV Partners p7
Nomura International p11
Nomura Phase 4 Ventures p1
Northwest Kinetics p5
Northwestern University p12
Novare Surgical Systems p8
Novartis p4
Novartis Venture Fund p7
NovImmune p7
Novo Nordisk p7
NuScribe p5
NuVasive p3
O
Oakwood Medical Investors p8
Ofer Hi-Tech p10
Olympic Medical p5
Oncobionic p5
Orthologic p3
Oxford Bioscience Partners p7
P
PAREXEL p5
Parkway Regional Medical p5
Pharmaca Integrative Pharmacy p8
Pharmacopeia p10
PharmaForm p5
Pharmion Corporation p1
Pictet Private Equity Investors p7
Piper Jaffray p3
Plexxikon p5
Plymouth Health p5
Point Judith Capital p8
Posit Science Corporation p12
Prolacta Bioscience p8
ProlX Pharmaceuticals p5
ProNAi Therapeutics p8
ProSeed Venture Capital p8
Protalex p3
Psychiatric Solutions p5
Public Health Trust p5
Punk, Ziegel. p3
Q
QIAGEN p5
R
Raymond James p3
RBC p3
Regency Care p5
Roche Holding p5
Rock Maple Ventures p7
Rodman & Renshaw p10
RxKinetix p5
S
Sadra Medical p8
Santhera Pharmaceuticals p8
Schering-Plough p5
Schroder Investment Management p8
SHG Holding Solut. p3
Shire plc p4
Sirna Therapeutics p5
Sofinnova Partners p7
South Broward Hosp. p5
Spark Capital p8
SR One p7
StatSure Diagnostic p3
Stericycle p9
Stiefel Laboratories p5
Stifel Nicolaus p3
Sun Healthcare p5
T
T2C2/Bio2000 p7
TA Associates p4
Takeda Pharmaceutical p5
Temasek Holdings p10
Texas Pacific Group p5
Themelios Venture Partners p8
TheraPei Pharmaceuticals p5
Thermage p3
Thomas Weisel Partners p6
Thoratec p5
Ticonderoga Capital p8
Treemont Retirement p5
Trevi Health Ventures p8
Trubion Pharmaceut. p3
Tudor Investment Corp. p8
U
UBS p3
Unilever Technology Ventures p8
Urigen p5
Uroplasty, Inc. p3
V
Valentis p5
Valhalla Funds p8
VaxInnate Pharmaceuticals p7
Vemics p5
Vical Incorporated p10
Viragen p3
Vision Systems Limited p5
Vision-Ease Lens p3
W
Wachovia p3
WHI Group p8
Worcester Polytechnic Institute p12
X
Xencor p7
Xenon p5
Xthetix p8
Z
Zen Investments p7 |
Out Of The Waiting Room, Please - Funding To
Reduce Costs, Improve Care Through Outpatient Facilities
Email Editor
Chronicity, Inc.
secured $12.5 million in its first round of equity funding, led by
Chrysalis Ventures. Operating under the name ADD Health and
Wellness Centers, Inc., Chronicity aims to offer an integrated and
customized approach to treating attention deficit disorder, or ADD, as
well as attention deficit hyperactivity disorder, or ADHD, and related
disorders. The proceeds from the financing will be used primarily to
support the launch of treatment centers throughout the United States,
beginning with the Dallas, Texas and Boston, Massachusetts metropolitan
areas. We talked with Koleman Karleski, a managing director at Chrysalis
Ventures, about the deal.
Chrysalis finds Chronicity
appealing "for two reasons. First, the traditional health care system is
failing people with chronic, complex medical conditions. And second, as
individuals begin paying more for their health care, which the industry is
calling consumerism, we believe they will demand a better consumer
experience and higher quality outcomes." Chronicity is pioneering a
business model, in the area of ADD/ADHD treatment, based on the idea of
providing patients with multiple services in one place, as a one-stop
alternative to visiting separate offices for medical, testing and
counseling services. The company utilizes a proprietary treatment
algorithm that includes nutritional counseling, medication management,
psychological services, skills coaching and an outcome management system.
The goal is to offer more focused and comprehensive care than primary care
physicians. In addition, Chronicity is maintaining a database of outcomes
that quantitatively monitors and measures the success of the program.
The
entrepreneur responsible for the idea is the same one who founded
Fibromyalgia and Fatigue Centers, Inc. (FFC) and grew that company to
15 centers, Mr. Robert Baurys II. Now he is the Chief Executive Officer of
Chronicity, and described by Mr. Karleski as "brilliant, an outstanding
entrepreneur." Chrysalis and Mr. Baurys became familiar with each other
when FFC was raising a venture capital round about four years ago.
Although Chrysalis was outbid in that deal, the firm is glad to invest in
Chronicity, which we were told is well-financed for years to come with the
$12.5 million round. Mr. Karleski believes that with the proceeds, the
company will be able fully cover its efforts in the area of ADD/ADHD, and
possibly foray into other clinical indications.
"People will
be spending more of their own money on health care in the coming years,"
Mr. Karleski says, therefore demanding better service and higher quality
from providers for their care. Chrysalis is very focused on supporting
businesses that enhance productivity as well as those that "help enable
the growing consumerism movement," he said. FFC has proven the model of
utilizing the outcomes database and tailored treatment approach.
Chronicity and its investors also know from FFC that with 100%
private-paying patients, a treatment center has the potential to turn
profitable in as little as a few months. We understand FFC is pulling in
tens of millions in revenue already, with no reimbursement accepted but
great patient retention. The comprehensive approach to a treatment plan
has been well received and the outcomes data very helpful in assessing
performance.
Chronicity
seeks to become a leader in the treatment of chronic disorders, with
ADD/ADHD as the first therapeutic area the company is addressing.
Chrysalis Ventures is expecting to keep Chronicity in its portfolio for
about the next five years and hoping for a return of five to ten times its
investment. Mr. Karleski expects that if all goes well, Chronicity will
serve as a platform to base other clinical or therapeutic businesses on,
or to layer with other complementary business units. Some of the funding
from Chronicity’s first round will be used for working capital and may
even fund efforts to expand into the treatment of other chronic disorders.
Although we hear some ideas are percolating, at this time the company is
not disclosing exactly what other treatment areas are under consideration.
Overall, the
goal is to "create a microcosm of what a good health care system would
be—providing a place for an integrated set of services culminating in a
treatment plan is the idea," Mr. Karleski told us, "and holding providers
accountable for outcomes." In addition, he explained that Chronicity’s
model offers patients an improvement over existing treatment options,
which at best could result in several visits to several different places
and at worst could result in children receiving nothing more than a
diagnosis and some drugs.
Chronicity is
not the only company looking more closely at the market for ADD/ADHD
treatment, which recent data indicates is expanding. According to an
analysis of health care claims presented by Shire plc (NASDAQ:
SHPGY) in October, many adults with a depressive disorder, bipolar
disorder or anxiety disorder may also have undiagnosed ADHD. In just the
claims Shire studied, managed care companies reported a total of 900,897
new diagnoses of ADHD and close to 20,000,000 cases of the other
disorders. Of the patients initially diagnosed with bipolar disorder, 2.5%
were also diagnosed with ADHD, and of those with depressive or anxiety
disorder, 1.7% were also diagnosed with ADHD.
About
4,400,000 children aged four to 17 years have been diagnosed with ADHD at
some point in their lives, according the Centers for Disease Control
and Prevention (CDC), meaning about 8% of school-age children.
Although there is no cure, there are accepted treatments that specifically
target the symptoms of ADD/ADHD, including educational approaches,
psychological or behavioral modification, and medication, such as Ritalin,
Adderall and Concerta. Drugless treatment is championed by some who say
that people suffering from these disorders can learn to embrace their
ADD/ADHD traits and turn them into channeled, positive strengths and
assets.
These drugs
are the subject of some controversy, with some suggesting that they are
prescribed too widely, particularly to children, and others concerned with
the potential for abuse. Novartis (NYSE: NVS), the producer of
Ritalin, also offers a sustained-release formulation of the drug, Ritalin
SR, which may lessen the potential for abuse of the drug as a stimulant.
Concerta, another extended-release form of methylphenidate hydrochloride
(the same active ingredient in Ritalin) may be associated with a lower
likelihood of abuse than immediate-release methylphenidate hydrochloride,
according to a new study announced at the end of October by McNeil
Pediatrics. McNeil’s study found that its extended-release formula was
less likely to produce subjective effects such as high or euphoric
feelings in healthy adults with a history of occasional stimulant use.
Strattera, a
selective norepinephrine reuptake inhibitor that is the first
non-stimulant drug approved by the FDA to treat ADHD, was used in another
recent study that links ADHD and learning disabilities, including reading
disorders such as dyslexia. Eli Lilly and Company (NYSE: LLY)
manufactures Strattera, which had sales of $126.4 million in the third
quarter of 2006 and is approved for children, adolescents and adults. At
the end of October it was announced that Strattera was studied in children
and adolescents, aged 10 to 16, to measure its efficacy in treating the
symptoms of ADHD and also a reading disorder. Patients with ADHD alone
were compared to patients with ADD and a comorbid (existing
simultaneously) reading disorder. After 16 weeks on Strattera, both groups
of patients reported improvement in nearly 50% of ADHD symptoms like
inattentiveness, hyperactivity and impulsivity, and the group with reading
disorders displayed improvement in reading decoding and comprehension.
Perhaps unfortunately for some of the older boys and men on the drug, a
possible side effect of Strattera could be priapism, a painful or
prolonged erection lasting for more than four hours.
In an
unrelated deal, another company received funding to support its strategy
for providing a new point of contact to improve the delivery of health
care, but it is focused on a very different therapeutic area. American
Access Care (AAC) completed a $130 million recapitalization with TA
Associates. Unfortunately, we were unable to ascertain the exact
amount of the equity investment, although we know a portion of the deal
was equity and the rest debt. AAC is a growing operator of vascular
centers serving patients with end-stage renal disease (ESRD), or kidney
failure, focused specifically on vascular access. The vascular access
point, typically in the forearm, is where a device is surgically implanted
in a dialysis patient and is the patient’s lifeline, providing the link
between person and dialysis machine. AAC is focused on maintaining the
integrity of the access point, which can be degraded by a malfunction or
blood clot that is dangerous to the patient and inhibits treatment.
According to
David Lang, a managing director at TA Associates, AAC’s "focused delivery
model provides tremendous savings to the health care system while offering
a higher quality patient experience and outcome." At its centers AAC
offers interventional services, including angioplasty, to open up a vein
in the case of stenosis, thromboectomy, to remove a blood clot at the
access point, as well as catheter placement and replacement. Historically,
such procedures have been performed in hospitals, with long wait times,
overnight stays and subsequently high costs as common results.
Among the
more than 330,000 ESRD patients receiving dialysis in the United States,
approximately 500,000 vascular access procedures are performed each year.
Currently AAC, founded in 2001, operates 14 facilities throughout the
Mid-Atlantic and Northeast. ESRD patient growth averaged 6% over the past
decade and is expected to continue at nearly the same rate through 2010.
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