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November 2006 issue

Out Of The Waiting Room, Please - Funding To Reduce Costs, Improve Care Through Outpatient Facilities
Clinical centers established to specifically concentrate on addressing a single disorder or therapeutic area are attracting the attention of investors.
...
Corporate Incubation Leads To Spin-Out - Equity Round Supports Clinically Established Delivery Technology
Although five health care companies priced IPOs during October, only one saw its stock value increase significantly in after-market performance.
...
Mergers & Acquisitions
Health care mergers and acquisitions continued at a steady pace, and more deals than usual came with prices during the month of October.
...
Venture Capital Market
The companies that raised larger rounds this month include a medical malpractice insurer and a medical waste management company.
...
Private Equity Market
Biopharmaceutical companies raised some of the larger private equity financings announced during October, and one pharma collected a milestone payment as well as a funding round.
...
Notes & Briefs

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Companies Mentioned in this issue:
November 2006

3i Group p7, p8
3M Company p5
5AM Ventures p8
A
AAIPharma p8
Abingworth Management p7
Abingworth Mgmt. p8
ABIOMED p3
ABN AMRO Capital Life Sciences p7
ABN AMRO Life Sciences p8
Accentia Biopharmaceuticals p10
Acchillion Pharmaceuticals p6
Achaogen p8
Acorda Therapeutics p10
Action Pharma p8
ActivBiotics p3
Advent Ventures p8
AGI Dermatics p8
Allied Waste Industries p8
Alsius p5
Alternative Behavioral Services p6
Alvarado Hospital Medical p5
ALZA Corporation p1
Amedisys p3
American Access Care p4
Amsterdam Molecular Therap. p8
Amyris Biotechnologies p8
AngioDynamics p5
AnorMED p5
Apjohn Ventures p8
Aradigm p3
Aravis Venture p7
Arcturus Capital p8
Arrowhead Research p8
Asthmatx p3
AstraZeneca p12
Atrium Biotechnol. p3
Avantis Medical Systems p8
Avista Capital Partners p8
AXA Private Equity p7
Axia Health Management p5
B
Beckman Coulter p5
Berna Products p5
BFI Medical Waste p8
BIOAM/Bioamgestion p7
Bioenvision p3
Biofisica p8
Biomira p5
Biotrace International p5
BioVex Gr p3
Boehringer Ingelheim p5
Borealis Infrastructure p5
Boston Scientific p8
Bristal p5
Brontes Technologies p5
Browning Ferris Industries p8
Burrill & Company p7
BZ Bank p7
C
Cadence Pharmaceu. p3
Caisse de Depot et Placement du Quebec p7
California Clinical Trials p5
Cambrex p5
CambridgeSoft p8, p9
Canaan Partners p7
Caremark Rx p6
Carrick Institute p12
Catalyst Pharmaceut. p3
CB Health Ventures p7
CDC Entreprises Innovation p7
Cell Therapeutics p3
Center for Neuroprosthetics and BioMEMS p12
Center for Untethered Healthcare p12
Centers for Disease Control and Prevention p4
Charles River Labor. p5
Chart Venture Partners p8
Chartwell Seniors Hsg. p5
Chattem p5
CHL Medical Partners p9
Chronicity p1
Chrysalis Ventures p1
CIBC p3
Citigroup p3
Clarient p8
CNF Investments p8
CNS p5
CoDa Therapeutics p8
Cogene Biotech Ventures p7
Connetics p5
Cowen & Co. p3
Craig-Hallum Capital p3
Credit Agricole Private Equity p7
Credit Suisse p3
Crucell p5
CVS p6
Cypress Group p9
Cytheris p7
Cytyc p5
D
Danaher p5
Dawson James p3
Derma Sciences p3
DFJ Mercury p8
Diffusion Pharmaceuticals p8
DoctorsDirect.com p8
Domain Associates p8
Domain Venture Partners p8
Drug Royalty Corp. p5
Dynavax Technolog. p3
E
EarlySense p8
Edison Venture p8
Efficas p8
eHealth, Inc. p3
Eli Lilly and Company p4
Emergent BioSolut. p3
Emeritus Assisted Lvg. p5
Endo Pharmaceuticals p5
EnVivo Pharmaceuticals p8
Erasmus Louisiana Growth Fund p7
Esperance Pharmaceuticals p8
Etgar Challenge Fund p8
Exelixis p3
F
Fibromyalgia and Fatigue Centers p2
Fidelity Biosciences p8
Finistere Partners p8
First Albany p3
Flagship Ventures p7
Fleming Family & Partners p8
Forbes Medi-Tech p5
Forward Ventures p7
FoxHollow Technol. p3
Fresenius Medical p5
Friendship Village Center p5
G
GE Healthcare Financial Services p8
Genaco Biomedical p5
Gentium p3
Genzyme p5
Geron p3
GetWellNetwork p8
Gilead Sciences p5
GlaxoSmithKline p5
Global Life Science Ventures p8
Grand Angels p8
Great Point Partners p10
Grosvenor Funds p8
Growth Foundation p8
H
Hansen Medical p3
Harborside Healthcare p5
HBM BioCapital p8
HBM BioVentures p8
HBM Partners p1, p7
Health Care Ppty. Inv. p3
Healthcare Brands International p7
Healthcare Svcs. Grp. p3
HealthCare Ventures p7
HealthSpring p3
Healthways p5
Helica Instruments p5
HemoSense p3
Highland Capital Partners p8
Hippo Ventures p8
HLM Venture Partners p8
Hollywood Medical Ctr. p5
Horizon Bay Management p5
HSBC p3
Hunt BioVentures p7
I
Icos p5
Imperial Innovations p8
InforSense Limited p8
InfuSystem p5
InnovationsKapital p8
Innovative Biosensors p8
Insception Biosciences p8
Insert Therapeutics p8
IntegriChain p8
Intelligent Medical Implants p8
Investor Growth Capital p7
Ithaka Acquisition p5
Ivivi Technologies p3
J
JMP Securities p6
Johnson & Johnson p1
JPMorgan p3
K
Keller Group p5
Khosla Ventures p8
Kleiner Perkins Caufield & Byers p8
L
LAB International p5
Lazard Capital p10
LeMaitre Vascular p3
Lexicon Genetics p10
LM Partners p10
Logical Images p8
Lombard Odier Darier Hentsch p7
Long River Ventures p8
Lonza Group p5
Louisiana Fund I p8
LSP BioVentures p8
Lumenis Limited p10
Lumigen p5
M
Macroflux Corporation, p1
Marcus & Millichap p5
Maxim Group p3
McNeil Pediatrics p4
MDS Capital p7
MedCath p3
MEDecision p3
Medicus Insurance Holdings p7
MedImmune Ventures p7
MedPointe p9
MedServe p8
MedVentive p8
Memory Pharmaceuticals p10
Merck & Co. p5
Merrill Lynch p3
Merriman Curhan Ford p10
MMV Financial p8
Montreux Equity Partners p8
Morgan Stanley p3
Morgenthaler Ventures p7
Morphotek p7
MPM Capital p10
mtm laboratories p8
MultiCell Technol. p3
Murphree Venture Partners p7
MVM Limited p7
Myogen p5
N
Nabi Pharma. p5
Nanogen p5
NAPC p5
National Association of Medical Sales Representati p12
National Dentex p5
Natus Medical p5
NContact Surgical p8
New Enterprise Partners p1
Newbridge Secs. p3
NGN Capital p8
NightHawk Radiology p3
NJTC Venture Fund p8
NLV Partners p7
Nomura International p11
Nomura Phase 4 Ventures p1
Northwest Kinetics p5
Northwestern University p12
Novare Surgical Systems p8
Novartis p4
Novartis Venture Fund p7
NovImmune p7
Novo Nordisk p7
NuScribe p5
NuVasive p3
O
Oakwood Medical Investors p8
Ofer Hi-Tech p10
Olympic Medical p5
Oncobionic p5
Orthologic p3
Oxford Bioscience Partners p7
P
PAREXEL p5
Parkway Regional Medical p5
Pharmaca Integrative Pharmacy p8
Pharmacopeia p10
PharmaForm p5
Pharmion Corporation p1
Pictet Private Equity Investors p7
Piper Jaffray p3
Plexxikon p5
Plymouth Health p5
Point Judith Capital p8
Posit Science Corporation p12
Prolacta Bioscience p8
ProlX Pharmaceuticals p5
ProNAi Therapeutics p8
ProSeed Venture Capital p8
Protalex p3
Psychiatric Solutions p5
Public Health Trust p5
Punk, Ziegel. p3
Q
QIAGEN p5
R
Raymond James p3
RBC p3
Regency Care p5
Roche Holding p5
Rock Maple Ventures p7
Rodman & Renshaw p10
RxKinetix p5
S
Sadra Medical p8
Santhera Pharmaceuticals p8
Schering-Plough p5
Schroder Investment Management p8
SHG Holding Solut. p3
Shire plc p4
Sirna Therapeutics p5
Sofinnova Partners p7
South Broward Hosp. p5
Spark Capital p8
SR One p7
StatSure Diagnostic p3
Stericycle p9
Stiefel Laboratories p5
Stifel Nicolaus p3
Sun Healthcare p5
T
T2C2/Bio2000 p7
TA Associates p4
Takeda Pharmaceutical p5
Temasek Holdings p10
Texas Pacific Group p5
Themelios Venture Partners p8
TheraPei Pharmaceuticals p5
Thermage p3
Thomas Weisel Partners p6
Thoratec p5
Ticonderoga Capital p8
Treemont Retirement p5
Trevi Health Ventures p8
Trubion Pharmaceut. p3
Tudor Investment Corp. p8
U
UBS p3
Unilever Technology Ventures p8
Urigen p5
Uroplasty, Inc. p3
V
Valentis p5
Valhalla Funds p8
VaxInnate Pharmaceuticals p7
Vemics p5
Vical Incorporated p10
Viragen p3
Vision Systems Limited p5
Vision-Ease Lens p3
W
Wachovia p3
WHI Group p8
Worcester Polytechnic Institute p12
X
Xencor p7
Xenon p5
Xthetix p8
Z
Zen Investments p7

Out Of The Waiting Room, Please - Funding To Reduce Costs, Improve Care Through Outpatient Facilities

Email Editor

Chronicity, Inc. secured $12.5 million in its first round of equity funding, led by Chrysalis Ventures. Operating under the name ADD Health and Wellness Centers, Inc., Chronicity aims to offer an integrated and customized approach to treating attention deficit disorder, or ADD, as well as attention deficit hyperactivity disorder, or ADHD, and related disorders. The proceeds from the financing will be used primarily to support the launch of treatment centers throughout the United States, beginning with the Dallas, Texas and Boston, Massachusetts metropolitan areas. We talked with Koleman Karleski, a managing director at Chrysalis Ventures, about the deal.

Chrysalis finds Chronicity appealing "for two reasons. First, the traditional health care system is failing people with chronic, complex medical conditions. And second, as individuals begin paying more for their health care, which the industry is calling consumerism, we believe they will demand a better consumer experience and higher quality outcomes." Chronicity is pioneering a business model, in the area of ADD/ADHD treatment, based on the idea of providing patients with multiple services in one place, as a one-stop alternative to visiting separate offices for medical, testing and counseling services. The company utilizes a proprietary treatment algorithm that includes nutritional counseling, medication management, psychological services, skills coaching and an outcome management system. The goal is to offer more focused and comprehensive care than primary care physicians. In addition, Chronicity is maintaining a database of outcomes that quantitatively monitors and measures the success of the program.

The entrepreneur responsible for the idea is the same one who founded Fibromyalgia and Fatigue Centers, Inc. (FFC) and grew that company to 15 centers, Mr. Robert Baurys II. Now he is the Chief Executive Officer of Chronicity, and described by Mr. Karleski as "brilliant, an outstanding entrepreneur." Chrysalis and Mr. Baurys became familiar with each other when FFC was raising a venture capital round about four years ago. Although Chrysalis was outbid in that deal, the firm is glad to invest in Chronicity, which we were told is well-financed for years to come with the $12.5 million round. Mr. Karleski believes that with the proceeds, the company will be able fully cover its efforts in the area of ADD/ADHD, and possibly foray into other clinical indications.

"People will be spending more of their own money on health care in the coming years," Mr. Karleski says, therefore demanding better service and higher quality from providers for their care. Chrysalis is very focused on supporting businesses that enhance productivity as well as those that "help enable the growing consumerism movement," he said. FFC has proven the model of utilizing the outcomes database and tailored treatment approach. Chronicity and its investors also know from FFC that with 100% private-paying patients, a treatment center has the potential to turn profitable in as little as a few months. We understand FFC is pulling in tens of millions in revenue already, with no reimbursement accepted but great patient retention. The comprehensive approach to a treatment plan has been well received and the outcomes data very helpful in assessing performance.

Chronicity seeks to become a leader in the treatment of chronic disorders, with ADD/ADHD as the first therapeutic area the company is addressing. Chrysalis Ventures is expecting to keep Chronicity in its portfolio for about the next five years and hoping for a return of five to ten times its investment. Mr. Karleski expects that if all goes well, Chronicity will serve as a platform to base other clinical or therapeutic businesses on, or to layer with other complementary business units. Some of the funding from Chronicity’s first round will be used for working capital and may even fund efforts to expand into the treatment of other chronic disorders. Although we hear some ideas are percolating, at this time the company is not disclosing exactly what other treatment areas are under consideration.

Overall, the goal is to "create a microcosm of what a good health care system would be—providing a place for an integrated set of services culminating in a treatment plan is the idea," Mr. Karleski told us, "and holding providers accountable for outcomes." In addition, he explained that Chronicity’s model offers patients an improvement over existing treatment options, which at best could result in several visits to several different places and at worst could result in children receiving nothing more than a diagnosis and some drugs.

Chronicity is not the only company looking more closely at the market for ADD/ADHD treatment, which recent data indicates is expanding. According to an analysis of health care claims presented by Shire plc (NASDAQ: SHPGY) in October, many adults with a depressive disorder, bipolar disorder or anxiety disorder may also have undiagnosed ADHD. In just the claims Shire studied, managed care companies reported a total of 900,897 new diagnoses of ADHD and close to 20,000,000 cases of the other disorders. Of the patients initially diagnosed with bipolar disorder, 2.5% were also diagnosed with ADHD, and of those with depressive or anxiety disorder, 1.7% were also diagnosed with ADHD.

About 4,400,000 children aged four to 17 years have been diagnosed with ADHD at some point in their lives, according the Centers for Disease Control and Prevention (CDC), meaning about 8% of school-age children. Although there is no cure, there are accepted treatments that specifically target the symptoms of ADD/ADHD, including educational approaches, psychological or behavioral modification, and medication, such as Ritalin, Adderall and Concerta. Drugless treatment is championed by some who say that people suffering from these disorders can learn to embrace their ADD/ADHD traits and turn them into channeled, positive strengths and assets.

These drugs are the subject of some controversy, with some suggesting that they are prescribed too widely, particularly to children, and others concerned with the potential for abuse. Novartis (NYSE: NVS), the producer of Ritalin, also offers a sustained-release formulation of the drug, Ritalin SR, which may lessen the potential for abuse of the drug as a stimulant. Concerta, another extended-release form of methylphenidate hydrochloride (the same active ingredient in Ritalin) may be associated with a lower likelihood of abuse than immediate-release methylphenidate hydrochloride, according to a new study announced at the end of October by McNeil Pediatrics. McNeil’s study found that its extended-release formula was less likely to produce subjective effects such as high or euphoric feelings in healthy adults with a history of occasional stimulant use.

Strattera, a selective norepinephrine reuptake inhibitor that is the first non-stimulant drug approved by the FDA to treat ADHD, was used in another recent study that links ADHD and learning disabilities, including reading disorders such as dyslexia. Eli Lilly and Company (NYSE: LLY) manufactures Strattera, which had sales of $126.4 million in the third quarter of 2006 and is approved for children, adolescents and adults. At the end of October it was announced that Strattera was studied in children and adolescents, aged 10 to 16, to measure its efficacy in treating the symptoms of ADHD and also a reading disorder. Patients with ADHD alone were compared to patients with ADD and a comorbid (existing simultaneously) reading disorder. After 16 weeks on Strattera, both groups of patients reported improvement in nearly 50% of ADHD symptoms like inattentiveness, hyperactivity and impulsivity, and the group with reading disorders displayed improvement in reading decoding and comprehension. Perhaps unfortunately for some of the older boys and men on the drug, a possible side effect of Strattera could be priapism, a painful or prolonged erection lasting for more than four hours.

In an unrelated deal, another company received funding to support its strategy for providing a new point of contact to improve the delivery of health care, but it is focused on a very different therapeutic area. American Access Care (AAC) completed a $130 million recapitalization with TA Associates. Unfortunately, we were unable to ascertain the exact amount of the equity investment, although we know a portion of the deal was equity and the rest debt. AAC is a growing operator of vascular centers serving patients with end-stage renal disease (ESRD), or kidney failure, focused specifically on vascular access. The vascular access point, typically in the forearm, is where a device is surgically implanted in a dialysis patient and is the patient’s lifeline, providing the link between person and dialysis machine. AAC is focused on maintaining the integrity of the access point, which can be degraded by a malfunction or blood clot that is dangerous to the patient and inhibits treatment.

According to David Lang, a managing director at TA Associates, AAC’s "focused delivery model provides tremendous savings to the health care system while offering a higher quality patient experience and outcome." At its centers AAC offers interventional services, including angioplasty, to open up a vein in the case of stenosis, thromboectomy, to remove a blood clot at the access point, as well as catheter placement and replacement. Historically, such procedures have been performed in hospitals, with long wait times, overnight stays and subsequently high costs as common results.

Among the more than 330,000 ESRD patients receiving dialysis in the United States, approximately 500,000 vascular access procedures are performed each year. Currently AAC, founded in 2001, operates 14 facilities throughout the Mid-Atlantic and Northeast. ESRD patient growth averaged 6% over the past decade and is expected to continue at nearly the same rate through 2010.

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Since 1948, Irving Levin Associates, Inc. has been the leading source of information and investment research on mergers and acquisitions in the Behavioral Health Care, Biotech, e-Health, Home Health Care, Hospitals, Laboratories, MRI and Dialysis, Long Term Care, Managed Care, Medical Devices, Pharmaceuticals, Physician Medical Groups, Rehabilitation and other health care markets.

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