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December 2006 issue

Open Window For Health Care: IPO Pricings Outnumber 2005, Expected to Continue in 2007
The health care IPO market has been more active this year, and the bankers we talked with did not seem to think it will be slowing down anytime soon.
...
The Case For Private Equity: One Biotech Tells Us What Lured It Away From The Public Market
Private equity deals offer a compelling alternative with advantages over the public market for companies in certain situations, including one in November.
...
Public Equity Market
Five health care companies priced IPOs, five priced secondary public offerings and two withdrew IPOs.
...
Mergers & Acquisitions
With four billion-dollar deals and several smaller ones, the health care M&A market is still in full swing.
...
Venture Capital Market
More than one trend is taking shape in health care, as investors show support for services businesses, in the bariatric market and others.
...
Private Equity Market
Private placement activity in the health care sectors during November, which included six deals for $40 million or more, was fairly average for the year.
...
Notes & Briefs

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Companies Mentioned in this issue:
December 2006

A
Abbott Laboratories p6
Abingworth Management p7
Accentia p3
Accuray p3
Acorda Therapeutics p1
ActivBiotics p3
AdCare Health Sys. p3
AdCare Health Systems p4
Advantage Capital Partners p8
Advantedge Healthcare Solutions p8
ADVENTRX Pharmaceuticals p10
Aegera Therapeutics p8, p9
Aesthetic Sciences p8
Affymax p3
Alba Therapeutics p8
Alexion Pharmaceu. p3
Allergan p8
Alliance Imaging p3
Alpha Associates p7
Alta Biopharma p8
Alta Partners p7, p8
Alteon p3
Amerigroup p4
Ampersand Ventures p7
Amphion Innovations p8
Anesiva p10
Apax Partners France p7
Aquilo Partners p9
Arcapita Ventures p8
ARCH Venture Partners p7
Arena Pharmaceut. p3
Artes Medical p3
AspenBio Pharma p3
Atel Ventures p8
Atlas Venture p7
Austin Ventures, p8
Aveta p4
Avida Group p7
B
Baker Brothers Investments p11
Bariatric Partners p9
Bay City Capital p8
Bear, Stearns p3
BioAdvance Greenhouse Fund p8
Biophan Technologies p3
BoneSupport AB p8
Boston Community Venture Fund p7
Boston Millennia Partners p8
Brookdale Senior Living p4
Brookside Capital Partners p7
Burrill and Company p7
C
California Lyme Disease Association p12
California Technology Ventures p8
Cambridge Devices p8
Cara Therapeutics p8
CardioMEMS p8
Caremark Rx p6
Catalyst Pharmaceuticals p2
CDIB p7
Celerity Partners p8
Celgene Corporation p3
Cell Therapeutics p3
Centene p4
Centers for Disease Control and Prevention p12
Cerenis Therapeutics p7
Chiasma p7
Citigroup p3
CMEA Ventures p7
CollaGenex Pharmaceuticals p10
Concert Pharmaceuticals p7
Conor Medsystems p6
Cordis p6
Cross Atlantic Partners p8
CVS Corporation p6
D
Daaichi Sankyo p11
DexCom p4
DoctorsDirect.com p12
Domain Associates p8
Dr. Reddy’s Labor. p3
DSM Venturing p8
E
Eastside Partners p8
EDF Ventures p7
Elan Pharmaceuticals p9
Elixir Parmaceuticals p9
Elixir Pharmaceuticals p7
Emergent BioSolut. p3
Endocare p3
EpiCept Pharmaceut. p3
Epix Pharmaceutic. p3
eStudySite p8
EyeGate Pharma p8
F
F-2 Ventures p7
Familymeds Group p3
Federated Kauffman Fund p11
FFP Holdings p8
First Albany Capital p4
Flagship Ventures p7
FMRC Family Trust p10
Founders Equity p8
Frazier Healthcare Ventures p8
Fusion Capital p3
G
Goldman, Sachs p3
Greenway Medical Technol. p8
Greylock Partners p7
H
H.I.G. Ventures p8
Hambrecht & Quist p7, p9
Hansen Medical p3
Health Hero Network p8
HealthCap p7, p8
HealthCare Ventures p8
HLM Venture Partners p8
I
iCardiac Technologies p8
IDev Technologies p8
Ignition Partners p8
Inamed p8
Infectious Diseases Society of America p12
Innoven Partenaires p8
InSite Vision p3
IntegraGen p8
InterWest Partners p11
Intradigm Corporation p8
Inverness Medical p3
Iomai Corporation p3
J
JAFCO, p7
Johnson & Johnson p6
Joseph Gunnar & Co. p4
JPMorgan Securities p3
K
Kalologie Skincare p8
Kalypsys p7
KBL Healthcare Ventures p7
Kingsbridge Capital p1
Kodiak Venture Partners p8
Kos Pharmaceuticals p6
KT Venture Group p7
L
Latterell Venture p8
Lazard p3
Lazard Capital Markets p10
Leerink Swann & Company p10
LifeMed Media p8
Lowrey Organ p12
M
Magellan Biosciences p7, p9
MannKind p3
Marina Urgent Care Center p12
Maverick Capital p11
Mayflower p7
McKesson p6
MedCath Corporation p3
Medecision p3
MedGenesis Therapeutix p8
MedMarket Diligence p12
Merck p11
Merlin Biosciences p7
Mesa Laboratories p3
Metabasis p1
Millennium Research Group p12
Mindray Medical p2
Morgan Keegan and Company p9
Morgan Stanley p3
Morgenthaler Ventures p8
MPM Asset Management p11
MPM BioEquities p7, p9
MPM Capital p7, p9
MVM Life Science Partners p8
Myconostica p8
N
Nanospectra Biosciences p8
Navigant Capital Advisors p9
NBGI Ventures p8
Needham & Company p10
Neurochem p10
Neurostar Solutions p8
Neurotech Pharmaceuticals p7
NEW Capital Fund p8
New England Partners Capital p7
New Leaf Venture Partners p7, p8, p9
New Leaf Ventures p11
Newbridge Securities p3
Newbridge Securities Corporation p4
NewHope Bariatrics p8
NewStar Financial p7, p9
Nexus Medical Partners p7
NIF, p7
NightHawk Radiology p4
Novelos Therapeut. p3
O
Obagi Medical p3
OcuCure Therapeutics p8
Oculus Innov. Scien. p3
Ofer Hi-Tech p7
Omega Fund p7
OMRIX Biopharmaceuticals p2
On Assignment p3
Optimer Pharmaceu. p3
Option Care p3
OrbiMed Advisors p7
OREXIGEN Therapeutics p7, p9
Osage Ventures p8
Osiris Therapeutics p2
OVP Venture Partners p8
Oxford Bio- Science Partners p7
Oxford Bioscience Partners p8
Oxford Finance Corporation p8
P
Pathway Medical Technologies p8
Per-Se Technologies p6
Pharmacyclics p3
Pharmos Corporation p3
Picchio Pharma p10
Piper Jaffray & Co. p2
Pound Capital p7
Power Corporation of Canada p10
Power Technology Investment Corporation p10
Psilos Group p8
Q
Quinnova Pharmaceuticals p8
QVT Fund p7
R
Regeneron Pharmac. p3
Renovar p8
Rivervest Venture Partners p8
Rodman & Renshaw p10
Roth Capital p3
S
Safeguard Scientifics p8
Santa Monica Bay Physicians’ Playa p12
SG Cowen p11
Skyline Ventures p7
SMBC Ventures p7
Sofinnova Partners p7
Solstice Neurosciences p9
Split Rock Partners p8
Sprout Group p7, p11
Square 1 Bank p8
St. Cloud Capital p8
Stanford Financial Group p9
Stifel Nicolaus p1
Stonehenge Capital p8
Stryker p12
SunTrust Robinson Humphrey p2
SV Life Sciences p7
Synta Pharmaceuticals p4
T
Talyst Systems p8
Tavistock Life Sciences p7
Texas Emerging Technology Fund p8
Thermage p3
ThinkEquity Partners p10
Thomas, McNerney & Partners p8
Three Arch Partners p7
Ticonderoga Capital p8
Transcend Medical p8
Tufts Center for the Study of Drug Development p12
TVM Capital p7
TVM Capital, p7
U
UBS Investment Bank p3
UBS Securities p10
V
VenGrowth Advanced Life Sciences Fund p8
Ventech p8
Versant Ventures p7, p8
Visicu p4
Vital Images p3
Volcano Corp. p3
Volcano Corporation p2
W
Wachovia Capital Partners p8
Wasatch Advisors p7, p9
WI Investment Partners p8
WorldHeart p3
X
Xanthus Pharmaceuticals p8
Y
Yaupon Therapeutics p8
YFY Bioscience p7
Z
Zila, Inc. p10
Zimmer p12

Open Window For Health Care: IPO Pricings Outnumber 2005, Expected to Continue in 2007

Email Editor

As of November 30, 2006, more initial public offerings had been completed by health care companies in 11 months than in all of last year. So far, 37 health care IPOs have been priced in 2006, just over the 35 in all of 2005. The extremes in aftermarket performance have reached higher highs, but no lower lows in 2006 than the previous year. We may not know exactly what the coming year holds for the health care IPO market, but the bankers who talked with us recently sounded fairly optimistic about the sectors they work in and gave us some ideas on where we are headed in 2007. Ongoing investor interest is expected in the health care service sectors, as well as in the health care technology sectors, including information technology, medical devices and also biotechnology, in spite of its challenges.

Scott Cousino, Managing Director at Stifel Nicolaus (NYSE: SF), made the point that, "In spite of the IPO market being challenging for life sciences companies right now, some of the best-performing health care stocks priced this year have been biopharmas." At this point Acorda Therapeutics (NASDAQ: ACOR), a biopharma, has witnessed the greatest change in its stock price since the IPO at $6.00 per share, having climbed 227% to close at $19.63 per share on November 30. The next greatest increase was posted by another biopharma, OMRIX Biopharmaceuticals (NASDAQ: OMRI), which is up 196% since the IPO. Volcano Corporation (NASDAQ: VOLC), a medical device company, has seen its stock price increase by 122% since the IPO. Osiris Therapeutics (NASDAQ: OSIR), also a biopharma, came in fourth with an almost 93% gain, and China-based Mindray Medical (NYSE: MR) is holding fifth place with a nearly 78% gain.

Regarding the biotechnology sector, Mr. Cousino sees "cyclical activity, but perhaps more extreme than the others." That’s not the only issue, because "there are so few buyers, and pricing is very hard to do," he said. One pharma company that Stifel Nicolaus has worked with that also just priced its IPO, Catalyst Pharmaceuticals (NASDAQ: CPRX), is hovering around the IPO price ($6.00) and "is more like a biotech," he said. Going forward, in the next year or two at least, he doesn’t expect the IPO market to slow down in health care. "There is a lot of potential for private health care companies to get early and mid-stage funding," he said, through the public market.

Duncan Dashiff, Head of Health Care Investment Banking at SunTrust Robinson Humphrey, stated that in the past couple of years, "IPO deal flow has been unusually consistent in the biotechnology and biopharmaceutical sectors and has driven the bulk of IPO volume in the health care segment." But, he admonishes, "biotechnology can be a choppy space." Valuation is being driven in these sectors based not only on the science behind the company, but also the stage of development and the market opportunity being addressed. Mr. Dashiff also observed, "Over the last 24 months, the market’s receptiveness to IPOs from medical device and information technology companies has expanded significantly."

Health care IT represents a growing market that Stifel Nicolaus will be targeting more heavily in the next five years. Dan Gulbrandson, Managing Director of Health Care Investment Banking at Piper Jaffray & Co., noted, "the health care IT market is very robust right now." Piper Jaffray was involved in two of the top three health care IPOs priced so far this year, based on aftermarket performance, Acorda Therapeutics and Volcano Corporation. Mr. Dashiff of SunTrust expects continued interest in public offerings from providers of information technology solutions within the health care industry. He pointed out, "The rate of spending growth in the health care information technology sector is outpacing other industries, and an IPO can be more than sufficient to capitalize these companies for a period of long-term growth."

Within the medical device sector, hotter areas include cardiology, diabetes and other metabolic diseases, kidney and renal therapies and peripheral artery disease. Also characterizing the medical device sector, current trends in effect include a movement towards miniaturization, producing finer, closer and less invasive tools for surgeries, imaging and diagnostics. "Although this year the IPO market has not been a great place, we have seen a steady stream of medical device IPOs," Mr. Cousino stated, but there has been mixed aftermarket performance. Mr. Dashiff reminded us, "The good news is that with respect to medical device companies, as compared with last time we were at a healthy point in the cycle, the companies are generally of a more mature nature this time around in that they are addressing larger market opportunities and have more well-developed reimbursement strategies." The market has already responded positively to IPOs in the areas of telemedicine and remote monitoring, including such companies as DexCom (NASDAQ: DXCM), NightHawk Radiology (NASDAQ: NHWK) and Visicu (NASDAQ: EICU). SunTrust believes there are several companies in the areas of telemedicine and remote monitoring that represent hybrids between "med-tech" and IT that will ultimately prove to be very attractive IPO candidates. One company SunTrust Robinson Humphrey is currently working with, we’re told, is a hybrid, medical device and IT company. Mr. Dashiff expects we will see more in the future from medical technology, IT and other companies that represent a convergence of these sectors "for specific health care applications and play on themes that have already evidenced interest in the public markets."

In the health care services sector, Mr. Dashiff observed, "The dilemma is that given the abundance of private equity capital and leverage available in the debt capital market, the IPO market may not be as appealing to privately-held services companies of scale. Although there is a nice supply and demand dynamic in the public market for health care services companies, a transaction with a private equity partner can be significantly more compelling in terms of valuation and near-term liquidity for existing shareholders." He believes the IPO market can still present an attractive alternative for health care services businesses, though, and, "there is a demand for health care services companies of scale to go public, like Brookdale Senior Living (NASDAQ: BKD), for example, which has been well-received since its IPO late last year." Areas where we may see market growth, Mr. Dashiff thinks, include consumer directed health care, disease management and retail health initiatives, which have received "abundant private equity backing, represent another area of convergence in health care and are creating some of the ‘new’ ideas in health care services."

Also looking forward, Mr. Cousino said, "One possibility for the public market in 2007 is that we will see more Managed Medicare plans and Medicare Advantage plan providers pricing IPOs, including special needs and disease management plans." Aveta, a Medicare Advantage plan provider focused on the chronically ill, has already filed, and Mr. Cousino indicated there is more going on in this space behind the scenes. The market for this type of plan may be at a similar point in a cycle, he thinks, as when Medicaid plan providers such as Amerigroup (NYSE: AGP) and Centene (NYSE: CNC) were pricing IPOs, about five years ago. We can only wait and see.

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