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Healthcare Corporate Finance News

April 2007 issue

$1.3 Billion To Fund March VC Deals - Wireless Monitoring Devices Take More Than 10% of Total
Deals in wireless cardiac monitoring, among other technology-based health care products and services, helped push the March venture capital total up to a record level, in terms of most funding raised in a single month.
...
Q1:07 VC Funding Hit New Record High - Investors From At Least One Major Firm Are Looking Forward
Health care venture capital investing reached a new quarterly high in the first quarter ended March 31, 2007, with more total dollars raised in one quarter than we have ever recorded.
...
Public Equity
The one health care IPO priced during March may not be doing so well, but strong performance from other public companies must be heartening, because several new IPOs were filed, and we look more closely at a few of these.
...
Mergers and Acquisitions
One very large pharma deal, plus the acquisition of a large managed care company by the largest insurer in the United States, made for an interesting month in the health care M&A market.
...
Private Equity
Two deals account for more than half of all the health care private equity funding raised during March, and a few biopharmaceutical companies figured prominently among the top private placements of the month.
...
Notes & Briefs

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Companies Mentioned in this issue:
April 2007

3i p7
3i Group p10
3SBio p3
454 Life Sciences p6
A
Abiomed p4
Adams Street Partners p10
Advent Venture Partners p9
Aegerion p4
Aeras Global TB Vaccine Foundation p10
Aerovance p8
Affinity Capital Management p8, p10
Ahura Scientific p10
Akzo Nobel p5
Alexza Pharmaceuticals p4
Alta Partners p8, p9
ALZA p9
Amarin Corporation p6
American Pharmacists’ Association p16
AmerisourceBergen p6
Amicus Therapeutics p4
Amira Pharmaceuticals p9
Apax Partners p8, p10
ARCH Venture p10
ARCH Venture Partners p10
Ascend Health p10
Astellas Pharma p6
Astion Pharma p10
Atlas Venture p10
ATS Medical p15
Aurora Scientific p8
AutoGenomics p10
Avalon Ventures p9
Axial Biotech p10
B
Baker Brothers p9
Banc of America p4
Banc of America Securities p3
Bathgate Capital Partners p15
Bay City Capital p9
Bayer Pharmaceuticals p8
BDC Venture Capital p10
Beckman Coulter p6
Bellco Health p6
Ben Franklin Technol. p10
BioFrontier Partners p2
BIOMEC p6
BioPartners Holdings p6
Biosite p6
Bioton p6
Boston Scientific p2
Brean Murray, Carret & Co. p15
Burrill & Co. p8, p10
C
Calistoga Pharmaceuticals p10
Calypte Biomedical p15
Camden Partners Holdings p10
Can-Fite Biopharma p15
Canaan Partners p8, p10
Candela p6
CardioNet p1
Cardium Therapeutics p12, p15
Care Investment Trust p3
Carl Zeiss Group p6
Castile Ventures p10
Caxton Advantage Life Sciences p10
CEGEDIM p6
Cell Therapeutics p15
Centene p12
Center for Venture Research at the University of N p16
Channel Medical p10
Chartwell REIT p6
Chelsea Therapeutics p15
China Biopharma p4
CHL Medical Partners p10
CIBC p4
CIBC World Markets p3
CircuLite p10
CIT Group p4
Citigroup p3, p4
Citigroup Global Markets p9
Clarus Ventures p8
CMEA Ventures p9
CNS Response p15
Coapt Systems p10
Cobalis p15
Community Health Systems p5
CompuMed p15
Conservatory Pond Res. p6
Corcept Therapeutics p15
CoreValve p10
CreditSuisse p14
Cross Creek Capital p10
Crucell N.V. p10
Cylex p10
Cytori Therapeutics p15
D
DanioLabs p6
DATATRAK International p15
David Khidasheli p15
Delphi Ventures p9
Dendrite International p6
Dextra Laboratories p6
Disc Dynamics p10
Domain Assoc. p10
Domain Associates p9, p11
E
Easton Capital p10
Easton Capital Partners p10
Eczacibisi Generic Pharm. p6
Eisai p6
Eli Lilly and Company p16
Emeritus Assisted Lvg. p6
EndoCeutics p4
Endocyte p10
Epiphany Biosciences p10
Essex Woodlands p7
etkon p6
European Drugs ETF p4
EUSA Pharma p1
Evotec p6
F
First Albany p4
Focus Informatics p6
Forbion Capital Partners p10
Foundation Medical Partners p2
Frazier Healthcare Ventures p10
G
GBS Venture Partners p9
Genta p15
Gentium p4
Georgia Venture Partners p11
Global Life Science Ventures p10
GlucoLight p10
Goldman Sachs p7
Goodbody p4
Granite Global Ventures p9
Greatbatch p6
Green Hospital Supply p15
Guideline p16
H
Hambrecht & Quist Capital Management p2
Harris & Harris Group p10
Health Benefits Direct p15
HealthShares p4
HealthStream p6
HemCon Medical Technologies p10
HLS p6
I
IDEO p2
Infectious Disease ETF p4
IngleWood Ventures p2
InnerCool Therapies p12
Inolase p6
Instant Technologies p6
Intarcia Therapeutics p9
Integra Ventures p10
IntelliDOT p10
International Academy of Compounding Pharmacists p16
International Council of Nurses p16
International Federation of the Red Cross & Red Cr p16
International Hospital Federation p16
Inverness Medical p6
Iomai p12
J
Jackson Organization p6
Jazz Pharmaceuticals p3
Johnson & Johnson Development p10
JP Morgan Partners p9
JPMorgan p4
K
Kalorama Information p8
KBL Healthcare Acquisition Corp. II p4
KBL Healthcare Acquisition Corp. III p3
KV Pharmaceutical p6
L
La Jolla Cove Investors p15
La Jolla Pharmaceutical p4
Lehman Brothers p8
Les Jardins de la Gare p6
LifeHouse Retirement p6
Lilly MDR-TB Partnership p16
Liquidia Technologies p10
Lpath p15
M
MAP Pharmaceuticals p9
Matignon Technologies p10
Maverick Capital p10
MD-IT p5
Med Ad News p16
MedCath p4
Medical Dictation p5
MedPage Today p10
Memory Pharmaceuticals p7
Merck p6
Merrill Gardens p6
Merrill Lynch p3, p4
Merrion Pharmaceuticals p3
Microbia p9
Midsummer Investment p15
Milestone Venture Partners p10
Mitsubishi International Corporation p9
Morgan Keegan & Company p5
Morgan Stanley p4
Morgan Stanley Investment Management p9
Morgenthaler Ventures p9
Morphotek p6
Mosaix Ventures p10
MPM Capital p7, p11
MultiCell Technologies p15
Mylan Laboratories p4
N
National Community Pharmacists Association p16
Needham & Co. p4
NeoMed p9
Neose Technologies p12
Neuralstem p15
Neuro-Hitech p15
Neuro3d p6
New England Financial of North Jersey p16
New Enterprise Associates p9
New Enterprise Associates p10
New Leaf Venture Partners p9
Nexus Health Systems p6
NGN Capital p10
NimbleGen Systems p4
Nitec Pharma p10
NLV Partners p10
Noesis Capital p15
Nomura Phase4 Venture p9
NovaCardia p4
Novadaq Technologies p6
NovaQuest p9
Novartis BioVenture Fund p9
Novelos Therapeutics p4
Novo A/S p9
Nuance Communica. p6
Numira Biosciences p10
O
Omega Fund p9
Omega Healthcare p4
OmniComm p15
OncoGenex p4
OPi SA p1
Oppenheimer & Co. p12
Organon BioSciences p5
Orqis Medical p10
Oxford BioMedica p6
Oxford Bioscience Partners p9
Oxford Biosciences p10
Oxxon Therapeutics p6
P
Pan Atlantic Bank and Trust Limited p8
Paperboy Ventures p15
PDSHeart p2
Peplin p7
Pequot Capital p10
Perrigo Company p6
Pharmasset p4
Phenomix p9
Picchio Pharma p10
Plus Orthopedics Holding p6
PneumRx p10
Pocono Medical Care p10
Polaris Venture Partners p8, p10
Potentia Pharmaceuticals p10
PreMD p15
Prisma, Yellin-Lapidot p15
Prognomix p10
ProQuest Invest- ments p9
Prospect Venture Partners p9
ProteoGenix p10
Psilos Group p10
pSivida p4
Q
Qualis p6
QuantRx Biomedical p15
Quark Biotech p4
Quilvest Ventures p9
R
RBC Capital Markets p15
Regado Biosciences p10
ReGen Biologics p15
Ridgeback Capital p9
Roche Holding p6
Rodman & Renshaw p15
S
Salk Institute p11
Sanarus Medical p10
Sanderling Venture Partners p10
Sanderling Ventures p2
sanofi-aventis p6
Schering AG Group p12
Schering-Plough p5
Scientific Intake p10
Select Medical p6
SenoRx p3
Sepracor p16
Siemens Venture Capital p10
Simcere Pharmaceuticals p3
Sirtris Pharmaceuticals p4
SJF Ventures p10
Smith & Nephew p6
SmoothShapes p10
Sofinnova Ventures p9
Solvay Pharmaceuticals p4
Spaltudaq p10
Split Rock Partners p10
Stereotaxis p12
Straumann Group p6
Summer Infant p4
Summerville Senior Living p6
Syndax p11
T
T.R. Winston & Company p15
Targanta Therapeutics p7
Tech Coast Angels p10
Telegraph Hill Partners p10
Teva Pharmaceutical Industries p8
Thallion Pharmaceuticals p12
Tharos Laboratories p16
Thomas Weisel p4
Three Arch Partners p10
Tissue Repair Company p12
Titan Pharmaceuticals p12
TongjiTang Chinese Medicine p3
Torch Hill Partners p10
TPG p6
TPG Growth p10
Transoma Medical p8, p10
Triad Hospitals p5
U
UBS Investment Bank p3, p4
UnitedHealth Group p5
UPS p8
Upstream Biosciences p15
Uroplasty p6
V
Vaccinex p8
Valeant Pharmaceuticals p4
VASTox p6
Venrock Associates p9
Ventas p4
VentiRx Pharmaceuticals p10
Versant Ventures p9
ViroPharma p12
vSpring Capital p10
W
Wakefield Group p10
Wasatch Advisors p10
Wellpartner p10
Wexford Capital p10
Windsor Bay Capital p10
Winner Medical p4
Wright Medical Group p6
X
Xradia p10
XShares Group p4
XTL Biopharmaceut p4
Z
Zentiva p6
ZIOPHARM Oncology p4

Q1:07 VC Funding Hit New Record High - Investors From At Least One Major Firm Are Looking Forward

Email Editor

Preliminary results indicate that venture capitalists invested a record amount, nearly $2.8 billion, in health care companies during the first quarter ended March 31, 2007. At least 130 deals with prices were announced during the quarter, the highest number we have on record for any single quarter. Total funding for this quarter is 25% higher than it was during the first, third and fourth quarters of 2006, which each saw $2.2 billion raised in health care venture capital. Biopharmaceutical companies attracted more than 26% of the total capital raised during the first quarter of 2007—more than twice as much as they did in the year-ago quarter. Most of the biopharmaceutical deals were larger, too, with an average size of $31.6 million, and including only a handful of rounds for less than $10 million. Biotechnology saw the greatest change in number of deals, with ten more announced during the first quarter of this year than last year, but saw a decrease in the total amount invested.

The two largest deals of the quarter, both announced in March, were the $175.0 million round raised by EUSA Pharma and the $110.0 million round raised by CardioNet. EUSA Pharma, a specialty pharma, used the proceeds from its March financing to acquire OPi SA, an integrated biopharma based in France. With offices in the United Kingdom and the United States, EUSA is working to create a platform for building a significant transatlantic business, starting with the OPi deal, which was funded by Essex Woodlands, 3i, Goldman Sachs and other investors. The third-largest deal of the quarter, a $70.0 million round, was announced in February by Targanta Therapeutics, a biopharma focused on developing and commercializing novel antibacterial agents to address unmet medical needs in the hospital market.

As the M&A market continues to provide many venture-backed companies with an exit opportunity, investors continue to fund growing health care companies that are expected to serve large markets or unmet medical needs. Recently, some of the partners at MPM Capital, a venture capital firm that just closed a $550.0 million fund dedicated to health care, offered some comments on the state of the industry right now. Not long after the firm announced the closing of its BioVentures IV fund, MPM announced that the new fund had actually made its first investment during the second quarter of 2006. MPM indicated that BioVentures IV is already generating a double digit internal rate of return for its investors, fueled by strong early performances from Memory Pharmaceuticals (NASDAQ: MEMY) and Peplin (ASX: PEP).

Founding general partner Ansbert Gadicke observed, "When we launched MPM, IPOs were the preferred exits; more recently, M&A has provided superior returns." Interestingly, we suspect that lately it has become a bit of a fashion statement for some companies to file for an IPO, when they really are trying to attract an M&A suitor, and that may not be a bad strategy. Others may just be focusing on getting some press, and we admit to wondering about a certain global private equity firm, plus a few health care companies that have filed and withdrawn IPOs two or three times in the past few years. MPM relates that the firm is ready to capitalize on current demand for promising opportunities primarily in the technology segment of health care.

Dr. Ashley Dombkowski, general partner of MPM Capital, commented, "Medical device investing continues as a critical component of our strategy. This is particularly true given the pressures on large and even mid-sized device companies to replenish their pipelines with innovative, high-growth products." She continued, "We have seen that if a device company has compelling proof-of-concept clinical trial results, and if the potential product looks like it could be a blockbuster, it may not need to go all the way to IPO to produce superior returns for its investors." The medical device arena, she noted, is fiercely competitive and, "Innovation is creating new blockbuster categories."

Regarding Pharmaceuticals, MPM general partner Dr. William Greene expressed optimism, remarking that the globalization of the biotechnology and pharma industries is, "far more than just outsourcing. MPM is well-positioned to lend support and experience as the worldwide life science industry creates jobs, improves health care access and provides new avenues for job creation." Insights from Steven St. Peter, M.D., an MPM general partner, include, "The boundaries of venture capital have extended well into the world of buyouts and private equity. As the buyout firms have moved up-market into mega- and club-deals, the opportunity to participate in health care growth opportunities in the middle market has been vacated." MPM Capital is confident about and prepared to play an important role in these types of investments.

So what prognostications does that lead us to, for health care venture capital fundraising during the rest of the year? Well, we hear the M&A market is not slowing down, and we know the health care IPO pipeline is continuing to fill, in part with companies we have seen raising venture capital over the past few years. With a growing number of venture-backed health care companies reaching phase III clinical development, big pharmas and biotechs in search of a promising compound or licensing deal should have a fair amount of strategic investment, partnering, licensing and M&A opportunities to choose from. Assuming the markets continue to offer VCs options for cashing out at attractive premiums, we presume VCs will keep funneling capital back into health care—especially as technological advancement, entrepreneurial innovation and, of course, financial and management prowess, continue to thrive in and drive the health care markets. Right now, it appears that the health care venture capital market is poised for another record year of fundraising.

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Since 1948, Irving Levin Associates, Inc. has been the leading source of information and investment research on mergers and acquisitions in the Behavioral Health Care, Biotech, e-Health, Home Health Care, Hospitals, Laboratories, MRI and Dialysis, Long Term Care, Managed Care, Medical Devices, Pharmaceuticals, Physician Medical Groups, Rehabilitation and other health care markets.

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