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In the September 2005 issue:

Novartis Offers to Buy Rest of Chiron Corp. for $4.5 Billion
Novartis AG wants to buy the remaining interest in vaccine maker Chiron Corp. that it does not already own. It has offered to pay $40 per share, but Chiron’s independent board appears to be holding out for a sweeter deal.
...
September’s Deals
Sixty-eight transactions were announced in the past four weeks. Based on revealed prices, a total of $7.4 billion was committed to fund them. Both the Biotechnology and Home Health sectors had an active month.
...
In The Departments
Services
- Health Care Services
- Deal Summaries
- Additional Transactions
- Transaction Updates

Technology
- Health Care Technology
- Deal Summaries
Additional Transactions
- Transaction Updates

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Companies mentioned in this issue:

A
A1 Nursing Registry p3
Abbott Laboratories p12
ABN Amro p13
Akzo Nobel NV p12
Alabama Vascular & Vein Center p8
Alnylam Pharmaceuticals p10
Alpharma p13
Alternative Behavioral Counseling p2
American Retirement Corporation p8
ANZ Bank p4
Applied Therapeutics p12
Arcapita p3
Ardent Health Services p3
Arrow Pharmaceuticals p12
Artesian Therapeutics p11
ArthroCare p12
B
Barr Laboratories p12
Beverly Enterprises p2
Biogen Idec p11
Boston Scientific p12
C
Calyon p13
CapitalSource Financing p7
Cardiome Pharma p11
CareerStaff Unlimited p9
Carnegie Wylie & Co. p12
Central Arkansas Hospital p3
Chiron Corp. p1
Cigna Corp. p3
Citi p13
Clal Biotechnology Industries Ltd. p11
Clal Industries and Investments Ltd. p11
Clinical Pathology Laboratories p4
CLW Health Care Services p8
Community Health Systems p4
Cordis p12
Corixa Corp. p11
Covance p9
Covance Clinical Research Unit, Inc. p9
Creative Computer Applications p12
Crossroads Regional Medical Center p4
Curative Health Services p9
Cyberquest p8
D
Deutsche Bank p13
Docpharma p13
E
EpiCept p13
Epoch Senior Living p8
Essent Healthcare p4
Eyetech p11
F
First Islamic Investment Bank p3
Formation Capital p7
G
Genentech p11
GlaxoSmithKline p10
Good Shepherd Health System p3
Group Health Cooperative p8
Guidant Corp. p12
H
HCA p4
Home Care Living p2
Horizon Health Corp. p9
I
IBA Health p12
ICICI Group p13
ICICI Venture p13
ID Biomedical p2
Image-Guided Neurologics p12
Integra LifeSciences Holding p12
Integrated Health p8
Interim Health Care Wyoming p3
J
Johnson & Johnson p12
JPMorgan p4
K
KPS Health Plans p8
L
Leisureworld Caregiving Centres p8
LHC Group p3
Lincare Holdings p2
Lovelace Health Plan p3
Lovelace Sandia Hospice p3
M
Mariner Health p8
Mary Immaculate Hospital p4
Matrix Laboratories’ p13
Maxim Pharmaceuticals p13
MEDICOM p12
Medtronic p12
Memorial Medical Center p4
Merck p10
Merrill Lynch Capital p8
Minnie G. Boswell Memorial Hospital p3
Musculoskeletal Transplant Foundation p12
N
National Naval Medical Center p4
NationsHealth p2
NDCHealth Corp. p2
NeighborCare p9
Newport Hospital and Clinic p4
NexMed p10
North American Senior Care p2
North Shore Long Island Jewish Health System p4
Northwest Neonatology Associates, P.S. p9
Northwestern Memorial Home Health Care p3
Novartis AG p1
O
OmniCare p9
Organon Ireland p12
Organon USA p12
OSI Pharmaceuticals p11
Osteotech p12
Oxford Bioscience Partners p11
P
Pacer Health Corp. p3
Pediatrix Medical Group p8
Per-Se Technologies p2
Pfizer p11
Piper Jaffray & Co. p13
ProCare One Nurse p9
Psychiatric Solutions p2
R
Radionics p12
Ranbaxy p13
Remington House p8
ResCare p2
Royal Senior Care p8
S
Sanofi-Aventis p10
Savient Pharmaceuticals p12
SeBo GmbH p10
Sigma Company Limited p12
Sonic Healthcare p4
Southern Plantation p8
Southern Plantation Development p8
SSM Health Care p4
St. Vincent Catholic Medical Center p4
StorComm p12
Summit Partners p4
Sun Healthcare Group p9
T
Tender Loving Care Health Services p3
Tenet Healthcare Corp. p4
Teva Pharmaceuticals p11
The Blackstone Group p13
The Carlyle Group p13
The Macquarie Power Fund p8
TLC In-Home Care p2
Triad Hospitals p3
Tyco Healthcare Group, LP p12
U
UBS p9
Universal Health Services p4
V
Vein Associates of America p8
VistaCare p3
W
Wachovia Bank p7
Wachovia Securities p13
Walter Reed Army Medical Center p4
West Pharmaceutical Services p9
White County Medical Center p3
Wizzard Software Company p3
Wockhardt p13
Wolters Kluwer p2
Wyeth p10

Novartis Offers to Buy Rest of Chiron Corp. for $4.5 Billion

Influenza pandemics have been traveling the world long before globalization spread business and industry over the face of the earth. Western Europe is currently worried by the possibility of avian flu reaching it from Southeast Asia. And, as autumn approaches, we are bracing for another season of a flu epidemic that could easily circle the globe.

Business follows opportunity, and the possible outbreak of these diseases on a worldwide scale does represent a distinct opportunity, if your company happens to manufacture and distribute vaccines on a global basis. It is estimated that the flu vaccine market could double to $3.6 billion by 2010, while the market for all vaccines could reach $10 billion as early as 2007.

With this in mind, Novartis AG (NYSE: NVS) has made an offer to buy the 57.8% it does not already own in Chiron Corp. (NASDAQ: CHIR), a vaccine maker, for about $4.5 billion. If consummated, this deal would strengthen NVS’ position among the world’s top five vaccine makers, currently Merck (NYSE: MRK), GlaxoSmithKline (NYSE: GSK), Wyeth (NYSE: WYE), Sanofi-Aventis (NYSE: SNY) and Novartis in fifth place.

Based in Emeryville, California, Chiron is about more than just vaccines. The company also derives its revenue from blood-testing, biopharmaceuticals and cancer therapeutics, as well as from royalty and licensing fees. Among the various corporate relationships it has forged over the years, CHIR has a decade-old history with Novartis that is well-defined by a variety of collaborations and agreements. On a trailing 12-month basis, CHIR generated revenue of $1.66 billion, EBITDA of $194 million and a net loss of $4.6 million. In the most recent quarter, biopharmaceuticals accounted for 37% of CHIR’s revenue, blood-testing for 32% and vaccines for 24%.

The big black mark on Chiron’s corporate performance, accounting in large part for its recent loss, resulted from the contamination found in its English and German flu vaccine-manufacturing facilities last year, a setback that caused it to shut them down, severely curtail vaccine production and leave the market in short supply. Just before that time, CHIR’s stock had been trading at $46 a share. But in the year since, the stock has not been able to make it to the $40 level—until, that is, NVS made its move.

Novartis is offering $40 in cash per share for the 57.8% of CHIR it does not already own, which works out to $4.48 billion. This purchase price implies a price tag of $7.75 billion for a 100% interest in CHIR, which in turn yields a price to revenue multiple of 4.7x. NVS’s bid offers CHIR shareholders a modest 10% premium over the stock’s prior-day trading price. However, the independent members of Chiron’s board have rejected Novartis’ offer as "inadequate," a view reinforced by a market which sent CHIR’s stock to above $42 per share. At press time, we had yet to hear from NVS as to what its next step would be. The number of moves and countermoves the players can make in this game, however, is somewhat limited. First of all, with NVS already owning over 42% of CHIR’s stock, no one else is going to enter the fray against NVS as a white knight.

Second, due to a number of agreements between the two, Novartis is effectively precluded from taking certain actions when it makes a buy-out offer such as the present one (for some light reading, try out the "Governance Agreement" and the "Proxy Solicitation and Voting Trust Agreement" in Chiron’s 10-K). If CHIR balks, as it seems to have done, NVS can request binding arbitration to determine a "third-party value" for CHIR, but CHIR can then delay that move for a year. If NVS doesn’t like the third-party valuation when it is presented, it can turn it down—but just once. If NVS then decided to make a second run at CHIR, it would have to abide by the price determined by the arbitrator. A tender offer is theoretically possible, but unlikely given the existing agreements between the two. And so on... The upshot is that we expect NVS will want to get this deal done and shore up its position in the global vaccine market. To do so, the company may raise its offer to between $44 and $46 per share, raising the price to the low $5 billion range.

In the meanwhile, Novartis is pressing ahead with several other deals. First, Germany’s SeBo GmbH is selling development and commercialization rights to its hyperphosphatemia treatment for patients in kidney dialysis to Novartis for an undisclosed amount. The product, a novel oral phosphate binder, is in Phase I clinical development, and will be developed by the transplantation and immunology business unit of Novartis. Second, NexMed (NASDAQ: NEXM) is licensing its experimental nail lacquer treatment for onychomycosis, or nail fungus, to Novartis for up to $51 million, including a $4 million upfront cash payment and $47 million in development and regulatory milestone payments. This topical treatment, if it comes to market, would complement NVS’s oral Lamisil treatment. By reducing the amount of drug absorbed into the blood stream, it would make NexMed’s candidate safer; however, the drug will not be ready for commercial sale until at least 2008. Third, Novartis is paying $56.8 million in an upfront payment to buy a 19.9% stake in Alnylam Pharmaceuticals (NASDAQ: ALNY) to help that company develop and market its RNA interference technology.

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